CapadullaPlus was launched in 2020 by C.V. Martins as an Online shop, offering Free Shipping Worldwide for most of Guyana’s famous Medicinal Barks like Capadulla, Locust, Rose of the Mountain and Monkey Ladder to mention just a few, all Grinded up to Powder and placed in Tea Bags for ease of Use and Good Extraction of Nutrients.

We are a long term family owned company committed to achieving excellence in everything we do, from our customers, team and also community. All our employees understand that the main requirement of their work is to ensure that all products meet our high standards of quality and food safety.

We adhere to all National and International quality standards and practices.

OFFICIAL CAPADULLA - (Doliocarpus dentatus) Capadula, Kabuduli, Kapadula, Sah-kah-ti-to, Liane Rouge is a wild crafted herb that grows naturally in Guyana and it draws all of its nutrients from the earth naturally. Capadulla is not farmed or sprayed with any kind of pesticide. It's grown on its own strictly through nature with no interference from man. Capadulla has been used by men to prevent and cure impotence, premature-ejaculation and to raise sexual libido. Get the same benefits from Capadulla as you do from Viagra without any negative side effects. The only requirement is that you must be taking capadulla for at least 24-72 hours. 1-3 teacups a day will boost results.

Other Benefits of Capadulla

Pain Releiver (Especially Back Pain)Natural Stimulant and gives energy and can replace coffee other energy beverages.Capadulla can be combined with a variety of aphrodisiac herbs and is commonly used with Jatoba Bark, Sarsaparilla, Granny Backbone, Cocolmeca, Monkey Ladder etc.PARTS USED: Whole plant – leaves, stem, root, bark, sap

Our Capadulla Plus Tea contains: Capadulla plus Devil Doer, Granny Backbone, Kufa, Locust, Monkey Ladder & Rose of the Mountain. We have also added some Cinnamon, Cloves, Nutmeg & Spice Leaves for Good Flavor.

We include a Food Safe – Reusable – Natural – Cotton Canvas Tea-Bag with every 1Lb of Tea .

These Cotton-Canvas Tea-Bags are the healthiest way to Brew Tea, compared to the Commercial Tea Bags that are mass produced and of which most contain micro-plastics, recycled-paper, and even glue. When hot water hits those bags you get a mix of toxic chemicals in your Tea. So it makes good sense to avoid those modern tea bags and return to the Traditional Methods of Brewing our Teas.

So using a Cotton-Canvas Tea Bag is a Good Health Choice and Tip. Spread the word please. Pass on this knowledge.

Our Capadulla Plus Tea contains: Capadulla plus Devil Doer, Granny Backbone, Kufa, Locust, Monkey Ladder & Rose of the Mountain. We have also added some Cinnamon, Cloves, Nutmeg & Spice Leaves for Good Flavor.

Preparation (How to Use): Boil root preferably in spring. 1/4 Cup of bark to 1 liter or water. Boil at medium to high heat for 15-25 minute. Bark can be used 5-7 times or more until it loses its color. You can drink unsweetened or add agave or date sugar. Keep in mind that processed sugar is not ideal for healthy circulation so use alkaline sweeteners if possible. Drinking on a regular and consistent basis is known to address sexual dysfunctions without side effects.

Disclaimer: This information is intended only as a general reference for further exploration, and is not a replacement for professional health advice. This content does not provide dosage information, format recommendations, toxicity levels, or possible interactions with prescription drugs. Accordingly, this information should be used only under the direct supervision of a qualified health practitioner such as a naturopathic physician.

Doliocarpus dentatus, popularly known as Guyanese Capadulla, is an importantmedical woody stem belonging to the Dilleniaceae family [1,2]. The D. dentatus speciesis commonly found in tropical rainforests in Central and South Americas, from Mexicoto South Brazil, and the Amazon region has the highest representation of the species [3].In Guyana, the woody vine of D. dentatus grows in mixed to evergreen lowland forests [4–7].The Capadulla woody vine is regarded locally as a powerful aphrodisiac [8,9]. The stemof the D. dentatus is used to make tea or drinks, which purportedly raises libido, curesimpotence, and improves sexual desire in men [9].In Guyana, the traditional use of D. dentatus has involved treating specific symptomsof diabetes, Leishmanial ulcers, and erectile dysfunction (ED), and supporting overallwell-being [10,11].

The presence ofpolyphenols is noteworthy as they possess antioxidant, anticancer, anti-inflammatory, cytotoxic, and antimicrobial properties, primarily due to their radical scavenging ability [81].These findings suggest that a further exploration of polyphenolic compounds in D. dentatusred and white ecotypes may hold potential as a therapeutic response to erectile dysfunction.Their beneficial effects, attributed to their diverse bioactivities, make them a promising areaof interest for potential therapeutic interventions

4.1.1. FlavonoidsFlavonoids are a class of secondary metabolites mainly composed of a benzopyronering that contains phenolic or polyphenolic groups at various locations [96] The biosynthesis of phenols relies on two pathways: the shikimic acid and malonic acid pathways [97,98].These compounds are predominantly present in various botanical sources, such as fruits,herbs, stems, grains, nuts, vegetables, flowers, and seeds [99,100]. The therapeutic efficacy and biological activity of these various plant components are attributed to thepresence of bioactive phytochemical substances [101]. Flavonoids may offer antioxidant,anti-inflammatory, anticancer, cardiovascular, and neuroprotective benefits [102], whichmay contribute to reducing several sexual dysfunctions, such as low sexual desire, erectileMetabolites 2023, 13, 1050 20 of 35dysfunction, an inability to achieve orgasm, and premature ejaculation, which are relativelycommon in men, even at a young age [103–108].

Specific plant sources contain a naturally occurring flavonoid glycoside called lyoniside, which has potent anti-inflammatory and antioxidant properties [201], and is putativelyidentified in Guyanese Capadulla. It functions as an antioxidant to protect cells from thedamage of harmful free radicals, which can accelerate aging and lead to chronic diseases.Furthermore, lyoniside has demonstrated its potential as a neuroprotective compound,protecting neurons and promoting brain health [202]. Although lyoniside research is still inits early stages, the novel findings indicate that it has a high potential for therapeutic use,particularly in treating inflammatory and oxidative stress-related diseases.

5. ConclusionsThe present study aimed to analyze the phytochemical profiles of D. dentatus ecotypesusing untargeted and semi-targeted plant metabolomics, employing liquid chromatographyin conjunction with electrospray ionization mass spectrometry. Our findings highlight thepresence of the diverse bioactive compounds in D. dentatus ecotypes, including polyphenolic compounds, such as epicatechin methyl gallate, catechin gallate, proanthocyanidinA2 and proanthocyanidin B2 isomers, quercetin 3 glycoside, apigenin, (+)-Catechin, leucocyanidin, anthocyanidin 3-O-beta-D-sambubioside, and resveratrol. These compoundsexhibited diverse beneficial biological activities.